Exfoliation / Renewal

Alpha Lipoic Acid

INCI: Thioctic Acid · CAS 1077-28-7

Alpha lipoic acid (thioctic acid) is a versatile antioxidant that is both water- and oil-soluble, used in skincare for antioxidant protection and a smoother, more refined-looking complexion.

INCIThioctic Acid
CAS1077-28-7
Also known asalpha lipoic acid, ALA
Use leveltypically 1–5%
Solubilityboth water- and oil-soluble (amphiphilic)
pH / stabilitymildly acidic
RegulatoryListed in EU CosIng

What it does

  • Provides broad antioxidant protection in both water and oil environments.
  • Supports a smoother, more refined-looking skin surface.
  • Used in anti-ageing and radiance formulas.

How it works

Alpha lipoic acid is unusual in being soluble in both water and oil, so it is widely documented to act as an antioxidant across skin compartments. It can be potent but is also unstable and has a characteristic sulphur odour, which shapes how it is formulated.

Use level

Typical use level
typically 1–5%

Commonly used at 1–5%. Higher levels can tingle in sensitive skin. Start lower to assess tolerance.

Formulation considerations

  • Amphiphilic; can be incorporated into the water or oil phase.
  • Prone to oxidation and has a sulphur odour; stabilise and consider fragrance masking.
  • Best in mildly acidic systems; protect from light.

What it pairs with & what to avoid

Pairs well with

  • Other antioxidants (vitamin C, E)
  • Hydrators and soothing actives

Use with care / avoid

  • High levels in reactive skin (tingling)
  • Prolonged light/air exposure without stabilisation

Regulatory status

Thioctic acid (alpha lipoic acid) is listed in the EU CosIng database and is a well-established antioxidant ingredient.

Common questions

What does alpha lipoic acid do for skin?

It is a dual water- and oil-soluble antioxidant that protects skin and supports a smoother, more refined surface.

What percentage of alpha lipoic acid is used?

Typically 1–5%; start lower in sensitive skin.

Why does alpha lipoic acid smell?

It contains sulphur, giving a characteristic odour that formulators manage with fragrance and stabilisation.

Related monographs

The SBCT Labs Ingredient Suite is a free, independent educational resource for cosmetic R&D teams and formulators. It is provided for reference only and is not sales material — SBCT Labs does not necessarily supply the ingredients described here.

About SBCT Labs →
Related SBCT actives

Need an active built for your brief?

The Ingredient Suite is free and educational. Separately, SBCT develops and supplies cosmetic actives — botanical, fermentation and synthesis — made in India, formulated to your concept. Tell us the concern and format and we’ll send an evaluation sample.