Exfoliation / Renewal

Adenosine

INCI: Adenosine · CAS 58-61-7

Adenosine is a nucleoside signalling ingredient used at low levels in skincare to support smoother texture and a reduction in the look of fine lines.

INCIAdenosine
CAS58-61-7
Also known asanti-wrinkle nucleoside
Use leveltypically 0.04–0.1%
Solubilitywater-soluble (better warm)
pH / stabilitybroad
RegulatoryListed in EU CosIng; recognised anti-wrinkle active in some markets

What it does

  • Supports smoother skin and a softened look of fine lines.
  • A gentle, well-tolerated anti-ageing signal active.
  • Works at very low use levels.

How it works

Adenosine is a naturally occurring nucleoside widely documented to support skin-cell processes linked to firmness and texture. It is recognised as an anti-wrinkle functional active in some regulatory systems and is effective at very low concentrations.

Use level

Typical use level
typically 0.04–0.1%

Used at low levels, commonly 0.04–0.1%. Dissolves better in warm water.

Formulation considerations

  • Water-soluble; dissolves more readily in warm water, then cool.
  • Effective at very low levels; broadly compatible and stable.
  • Gentle and non-irritating.

What it pairs with & what to avoid

Pairs well with

  • Niacinamide, peptides
  • Hydrators and antioxidants

Use with care / avoid

  • Over-dosing — it works at low levels

Regulatory status

Adenosine is listed in the EU CosIng database and is recognised as an anti-wrinkle functional active in some markets.

Common questions

What does adenosine do for skin?

It is a gentle signalling active that supports smoother texture and a softened look of fine lines.

What percentage of adenosine is used?

Very low — commonly 0.04–0.1%.

Is adenosine irritating?

It is generally very well tolerated and gentle.

Related monographs

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