Hydration / Barrier

Phytosphingosine

INCI: Phytosphingosine · CAS 554-62-1

Phytosphingosine is a naturally occurring sphingoid lipid (a ceramide building block) used in skincare to support the barrier, soothe and provide mild antimicrobial benefits.

INCIPhytosphingosine
CAS554-62-1
Also known assphingoid base
Use leveltypically 0.1–0.5%
Solubilityoil-soluble (needs heat)
pH / stabilityoil phase / emulsified
RegulatoryListed in EU CosIng

What it does

  • Supports the skin barrier as a ceramide precursor.
  • Soothes and helps calm blemish-prone, reactive skin.
  • Provides mild antimicrobial character.

How it works

Phytosphingosine is a sphingoid base — part of the ceramide family and a building block of barrier lipids. It is widely documented for barrier-support, soothing and mild antimicrobial activity, and is effective at very low levels.

Use level

Typical use level
typically 0.1–0.5%

Used at low levels, commonly 0.1–0.5%. Often paired with ceramides and cholesterol.

Formulation considerations

  • Oil-soluble; requires heat and emulsification.
  • Effective at low levels.
  • Pairs with ceramides, cholesterol and fatty acids.

What it pairs with & what to avoid

Pairs well with

  • Ceramides and cholesterol (barrier blend)
  • Niacinamide

Use with care / avoid

  • Poorly emulsified systems (uneven delivery)

Regulatory status

Phytosphingosine is listed in the EU CosIng database and is a well-established barrier-support ingredient.

Common questions

What does phytosphingosine do?

It supports the barrier as a ceramide precursor, soothes and offers mild antimicrobial benefits.

What percentage of phytosphingosine is used?

Low levels, commonly 0.1–0.5%.

Does it work with ceramides?

Yes; it is part of the ceramide family and pairs well with ceramides and cholesterol.

Related monographs

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