Soothing / Sensitive

Hypochlorous Acid

INCI: Hypochlorous Acid · CAS 7790-92-3

Hypochlorous acid (HOCl) is a mild, skin-compatible antimicrobial molecule (the same one produced by the body's own immune cells) used in skincare to cleanse and calm blemish-prone and sensitive skin.

INCIHypochlorous Acid
CAS7790-92-3
Also known asHOCl, electrolyzed water
Use leveltypically 100–500 ppm
Solubilitymiscible with water
pH / stabilitymost active ~4.5–5.5
RegulatoryListed in EU CosIng; also covered by biocidal frameworks in some uses

What it does

  • Gently reduces surface microbes without stripping the skin.
  • Calms blemish-prone, post-procedure and sensitive skin.
  • Non-stinging and microbiome-considerate compared with harsh antiseptics.

How it works

HOCl is the same molecule neutrophils produce as part of the immune response. It is widely documented as a fast, broad antimicrobial that is nonetheless gentle on skin, without the resistance and irritation associated with harsher agents. Its activity and stability depend on a mildly acidic pH (around 4.5–5.5), and it must be formulated and packaged to remain stable.

Use level

Typical use level
typically 100–500 ppm

Cosmetic products commonly use around 100–500 ppm. Stability is the main formulation challenge, so it must be suitably stabilised and packaged.

Formulation considerations

  • Water-miscible; stability is pH- and storage-dependent.
  • Most active and stable around pH 4.5–5.5.
  • Protect from light, heat and reactive contaminants; appropriate packaging is essential.

What it pairs with & what to avoid

Pairs well with

  • Centella and soothing actives (post-procedure)
  • Simple, low-reactivity systems

Use with care / avoid

  • Reducing agents and reactive ingredients that consume it
  • Conditions that shift pH out of the stable window

Regulatory status

Hypochlorous acid is listed in the EU CosIng database; certain antimicrobial uses may also fall under biocidal-product frameworks depending on claims and market.

Common questions

Is hypochlorous acid safe for skin?

Yes; it is the same gentle antimicrobial the body makes, and cosmetic-grade HOCl is well tolerated, including on sensitive and post-procedure skin.

What concentration of HOCl is used in skincare?

Commonly around 100–500 ppm.

Why does HOCl need special packaging?

It is reactive and can degrade with light, heat and contaminants, so stabilised formulation and suitable packaging are needed to keep it effective.

Related monographs

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