Electrochemically generated Hypochlorous Acid (HOCl) formulated with Centella Asiatica Leaf Extract for synergistic anti-inflammatory and wound-supportive activity. The same molecule produced by human neutrophils as the body's primary antimicrobial defense — now in a stable, skin-compatible cosmetic-grade system. Highly effective at functional concentrations with exceptional skin tolerance.
Centella Asiatica Leaf Extract (and) Sodium Chloride (and) Hypochlorous Acid
Full CoA including active HOCl concentration, pH, microbial limits, and heavy metals available in TDS. Active chlorine concentration data shared under NDA/confidentiality upon request.
HOCl is bactericidal, virucidal, and fungicidal at concentrations that are simultaneously safe for skin. Effective against Cutibacterium acnes, Staphylococcus aureus, and other skin-relevant pathogens.
HOCl modulates inflammatory cytokine pathways — reducing IL-1β, IL-6, and TNF-α expression. Centella Asiatica (Asiaticoside, Madecassoside) provides synergistic calming and wound-support activity.
HOCl is produced naturally by human neutrophils via the myeloperoxidase enzyme system as the body's primary innate immune defense. The most biologically compatible antimicrobial available in cosmetics.
Non-irritating, non-sensitizing at functional concentrations. Suitable for sensitive, compromised, and acne-prone skin. No resistance development risk unlike antibiotic-based actives.
Supports wound healing by reducing biofilm formation and creating a clean environment for epidermal recovery. Centella Asiatica enhances fibroblast activity and collagen synthesis in the healing zone.
Dual action — kills C. acnes and reduces the inflammatory cascade that drives acne lesion progression. Non-drying, unlike benzoyl peroxide or salicylic acid at comparable antimicrobial efficacy.
HOCl is produced by controlled electrolysis of sodium chloride solution — mimicking the in-vivo neutrophil mechanism. The result is a pure, stable HOCl system without residual chlorine gas or toxic byproducts.
HOCl penetrates bacterial cell walls and disrupts essential metabolic functions — denaturation of proteins, inhibition of enzyme activity, and disruption of DNA replication. Effective at concentrations far below cytotoxic threshold for human cells.
At cosmetic-grade concentrations, HOCl downregulates NF-κB activation — the master regulator of inflammatory cytokine production. Reduces redness, swelling, and inflammatory acne lesion progression.
Asiaticoside and Madecassoside from Centella Asiatica stimulate fibroblast collagen synthesis, accelerate wound re-epithelialisation, and provide additional anti-inflammatory activity via TGF-β pathway modulation.
Formulated at pH 4.5–5.0 — the stability window for HOCl that maximizes active concentration while maintaining skin-compatible acidity. Buffered to prevent pH drift that would accelerate chlorine loss.
| Parameter | Specification |
|---|---|
| Supplied Form | Ready-to-use aqueous solution. Use as supplied — do not dilute further without stability testing. |
| pH of Finished Formulation | Maintain pH 4.5–5.5 for HOCl stability. pH above 6.0 accelerates decomposition to hypochlorite (ClO⁻), reducing efficacy. |
| Incorporation | Add to aqueous phase last, at cool-down (below 30°C). Avoid mixing with reducing agents, high-dose Vitamin C, or transition metal salts (Fe²⁺, Cu²⁺). |
| Packaging | Opaque HDPE or amber glass. Avoid metal components in contact with product. Airless or sealed packaging to prevent chlorine off-gassing and concentration loss. |
| Stability Recommendation | Conduct HOCl concentration verification by iodometric titration or DPD colorimetry at T=0 and accelerated stability timepoints. ICH Q1A conditions. |
| Storage (bulk) | Store at 2–25°C, protected from light and heat. Do not freeze. Avoid contact with metal surfaces. Shelf life 12 months from date of manufacture under specified conditions. |
Full physicochemical specifications, active HOCl concentration data, microbial limits, and CoA available in Technical Data Sheet under confidentiality agreement.
Request the full TDS with concentration data, or order a sample for evaluation.