Electrochemically generated Hypochlorous Acid (HOCl) formulated with Centella Asiatica Leaf Extract for synergistic anti-inflammatory and wound-supportive activity. The same molecule produced by human neutrophils as the body's primary antimicrobial defense — now in a stable, skin-compatible cosmetic-grade system. Highly effective at functional concentrations with exceptional skin tolerance.
Centella Asiatica Extract, Hypochlorous Acid, Sodium Chloride
Centella Asiatica Extract: 84696-21-9 · Hypochlorous Acid: 7790-92-3 · Sodium Chloride: 7647-14-5
Full CoA including active HOCl concentration, pH, microbial limits, and heavy metals available in TDS. Active chlorine concentration data shared under NDA/confidentiality upon request.
HOCl is bactericidal, virucidal, and fungicidal at concentrations that are simultaneously safe for skin. Effective against Cutibacterium acnes, Staphylococcus aureus, and other skin-relevant pathogens.
HOCl modulates inflammatory cytokine pathways — reducing IL-1β, IL-6, and TNF-α expression. Centella Asiatica (Asiaticoside, Madecassoside) provides synergistic calming and wound-support activity.
HOCl is produced naturally by human neutrophils via the myeloperoxidase enzyme system as the body's primary innate immune defense. The most biologically compatible antimicrobial available in cosmetics.
Non-irritating, non-sensitizing at functional concentrations. Suitable for sensitive, compromised, and acne-prone skin. No resistance development risk unlike antibiotic-based actives.
Supports wound healing by reducing biofilm formation and creating a clean environment for epidermal recovery. Centella Asiatica enhances fibroblast activity and collagen synthesis in the healing zone.
Dual action — kills C. acnes and reduces the inflammatory cascade that drives acne lesion progression. Non-drying, unlike benzoyl peroxide or salicylic acid at comparable antimicrobial efficacy.
HOCl is produced by controlled electrolysis of sodium chloride solution — mimicking the in-vivo neutrophil mechanism. The result is a pure, stable HOCl system without residual chlorine gas or toxic byproducts.
HOCl penetrates bacterial cell walls and disrupts essential metabolic functions — denaturation of proteins, inhibition of enzyme activity, and disruption of DNA replication. Effective at concentrations far below cytotoxic threshold for human cells.
At cosmetic-grade concentrations, HOCl downregulates NF-κB activation — the master regulator of inflammatory cytokine production. Reduces redness, swelling, and inflammatory acne lesion progression.
Asiaticoside and Madecassoside from Centella Asiatica stimulate fibroblast collagen synthesis, accelerate wound re-epithelialisation, and provide additional anti-inflammatory activity via TGF-β pathway modulation.
Formulated at pH 4.5–5.0 — the stability window for HOCl that maximizes active concentration while maintaining skin-compatible acidity. Buffered to prevent pH drift that would accelerate chlorine loss.
| Parameter | Specification |
|---|---|
| Supplied Form | Ready-to-use aqueous solution. Use as supplied — do not dilute further without stability testing. |
| pH of Finished Formulation | Maintain pH 4.5–5.5 for HOCl stability. pH above 6.0 accelerates decomposition to hypochlorite (ClO⁻), reducing efficacy. |
| Incorporation | Add to aqueous phase last, at cool-down (below 30°C). Avoid mixing with reducing agents, high-dose Vitamin C, or transition metal salts (Fe²⁺, Cu²⁺). |
| Packaging | Opaque HDPE or amber glass. Avoid metal components in contact with product. Airless or sealed packaging to prevent chlorine off-gassing and concentration loss. |
| Stability Recommendation | Conduct HOCl concentration verification by iodometric titration or DPD colorimetry at T=0 and accelerated stability timepoints. ICH Q1A conditions. |
| Storage (bulk) | Store at 2–25°C, protected from light and heat. Do not freeze. Avoid contact with metal surfaces. Shelf life 12 months from date of manufacture under specified conditions. |
Full physicochemical specifications, active HOCl concentration data, microbial limits, and CoA available in Technical Data Sheet under confidentiality agreement.
Request the full TDS with concentration data, or order a sample for evaluation.